• J. Nedbal, P.S. Hobson, D. J. Fear, R. Heintzmann, H. J. Gould, Comprehensive FISH Probe Design Tool Applied to Imaging Human Immunoglobulin Class Switch Recombination, PLOS ONE7, e51675, 2012
  • S. Cox, E. Rosten, J. Monypenny, T. Jovanovic-Talisman, D. T. Burnette, J. Lippincott-Schwartz, G. E. Jones und R.Heintzmann.Bayesian localization microscopy reveals nanoscale podosome dynamics.  Nature Methods 9, 195-200, 2012
  • S. Munck, K. Miskiewicz, R. Sannerud, S. A. Menchon, L Jose, R. Heintzmann, P. Verstreken und W. Annaert, Sub-diffraction imaging on standard microscopes through photobleaching microscopy with nonlinear processing, J. Cell Science 125,2257-2266, 2012
  • O. Mandula, M. Kielhorn, K. Wicker, G. Krampert, I. Kleppe, and R. Heintzmann, Line scan – structured illumination microscopy super-resolution imaging in thick fluorescent samples, Optics Express 20, 24167-24174, 2012
  • T. Ach, G. Best, S. Rossberger, R. Heintzmann, C. Cremer, S. Dithmar, Autofluorescence imaging of human RPE cell granules using structured illumination microscopy Br J Ophthalmol 96:1141-1144, 2012


  • G. Best, R. Amberger, D. Baddeley, T. Ach, S. Dithmar, R. Heintzmann, C. Cremer, Structured illumination microscopy of autofluorescent aggregations in human tissue, Micron 42, 330-335, 2011


  • K. Wicker, R. Heintzmann, Single-shot optical sectioning using polarization-coded structured illumination, J. Opt. 12, 084010, 2010
  • R. Heintzmann, Correcting distorted optics: back to the basics, Nature Methods 7, 108-110, 2010
  • L. Schermelleh, R. Heintzmann, H. Leonhardt, A guide to super-resolution fluorescence microscopy, J. Cell Biol 190, 165-175, 2010


  • R. Heintzmann, M.G.L. Gustafsson, The requirements for sub-diffraction resolution in continuous samples, Nature Photonics 3, 362-364, 2009
  • G. Liaugaudas, A. T. Collins, K. Suhling, G. Davies, R. Heintzmann, Luminescence-lifetime mapping in Diamond, J. Phys.: Condens. Matter 21, 364210. 2009
  • K. Wicker, S. Sindbert, R. Heintzmann, Characterisation of resolution enhancing image inversion interferometers, Optics Express 17, 15491-15501, 2009
  • L. Hirvonen, K. Wicker., O. Mandula and R. Heintzmann, Structured illumination microscopy of a living cell, Europ. Biophys. J. 38, 807-812, 2009
  • A. H. Reshak, V. Sarafis, R. Heintzmann, Second harmonic imaging of chloroplasts using the Two-Photon Laser Scanning Microscope, Micron 40, 378-385, 2009


  • M.Beutler, K. Makrogianneli, R.J. Vermeij, M. Keppler, T. Ng T.M. Jovin, R. Heintzmann, satFRET: estimation of Förster resonance energy transfer by acceptor saturation, Eur. Biophys. J. 38, 69-82, 2008
  • A. Hoppe, S. L. Shorte, J. A. Swanson, R. Heintzmann, D-FRET Reconstruction Microscopy for Analysis of Dynamic Molecular Interactions in Live Cells, Biophys. J. 95, 400-418, 2008
  • M. Barszczewski, J. J. Chua, A. Stein, U. Winter, R. Heintzmann, F. E. Zilly, D. Fasshauer, T. Lang, and R. Jahn, A Novel Site of Action for a-SNAP in the SNARE Conformational Cycle Controlling Membrane Fusion, Mol. Biol. Cell 19, 776-784, 2008


  • K. Wicker and R. Heintzmann, Interferometric resolution improvement for confocal microscopes, Optics Express 15, 12206- 12216, 2007.
  • C. Ventalon, R. Heintzmann, and J. Mertz, Dynamic speckle illumination microscopy with wavelet pre-filtering, Opt. Letters 32, 1417-1419, 2007.
  • T. J. Siddiqui, O. Vites, A. Stein, R. Heintzmann, R. Jahn, and D. Fasshauer, Determinants of Synaptobrevin regulation in membranes, Mol. Biol. Cell 18, 2037-2046, 2007
  • R. Heintzmann. Estimating Missing Information by Maximum Likelihood Deconvolution, Micron 38, 136-144, 2007
  • R. Heintzmann and C.J.R. Sheppard. The Sampling Limit in Fluorescence Microscopy, Micron 38, 145-149, 2007


  • V. Sarafis, R. Heintzmann, A. Karnieli, Visualizing Cyanobacteria in Soil Crusts from a Semi-Arid Environment using Confocal Fluorescence Imaging, Phytomorphology 56, 1-4, 2006
  • R. Heintzmann and G. Ficz. Breaking the resolution limit in light microscopy, Briefings in Functional Genomics and Proteomics 5, 289-301, 2006
  • R. Heintzmann and P.A. Benedetti, High-Resolution Image Reconstruction in Fluorescence Microscopy with Patterned Excitation, Applied Optics 45, 5037-5045, 2006.
  • J. J. Sieber, K. I. Willig, R. Heintzmann, S. W. Hell, T. Lang,  The SNARE-motif is essential for the formation of syntaxin clusters in the plasma membrane, Biophys. J. 90, 2843–2851, 2006.
  • R. F. Carvalho, M. Beutler, K. J.M. Marler, B. Knöll, E. Becker-Barroso, R. Heintzmann, T. Ng and U. Drescher, Silencing of EphA3 through a novel cis interaction with ephrinA5, NatureNeuroscience 9, 322-330, 2006


  • Q.S. Hanley, K.A. Lidke, R. Heintzmann, D.J. Arndt-Jovin, T.M. Jovin. Fluorescence lifetime imaging in an optically sectioning programmable array microscope (PAM), Cytometry Part A, 67A, 112-118, 2005.
  • G. Ficz, R. Heintzmann, D.J. Arndt-Jovin. Polycomb group protein complexes exchange rapidly in living Drosophila, Development 132, 3963-3976, 2005.
  • K.A. Lidke, B. Rieger, T.M. Jovin, R. Heintzmann. Superresolution by localization of quantum dots using blinking statistics. Opics Express 13, 7052-7062, 2005.
  • S.T. Berezhnaa, S. Schaefer, R. Heintzmann, M. Jahnz, G. Boese, A. Deniz, P. Schwille. New effects in polynucleotide release from cationic lipid carriers revealed by confocal imaging, fluorescence cross-correlation spectroscopy and single particle tracking. Biochimica et Biophysica Acta, 1669, 193-207, 2005.
  • M. A. Andrei, D. Ingelfinger, R. Heintzmann, T. Achsel, R. Rivera-Pomar, R. Lührmann, A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies, RNA 11, 717-727, 2005


  • E.A. Jares-Erijman, C. Spagnuolo, L. Giordano, M. Etchehon, J. Kawior, M.V. Mañalich-Arana, M. Bossi, D.S. Lidke, J.N. Post, R.J. Vermeij, R. Heintzmann, K.A. Lidke, D.J. Arndt-Jovin and T.M. Jovin: Novel (bio)chemical and (photo)physical probes for imaging live cells. In: Supramolecular Structure and Function, Vol. 8, G. Pifat-Mrzljak (ed.) Kluwer-Plenum Publishers, Amsterdam, pp. 99-118, 2004.
  • H.E. Grecco, K.A. Lidke, R. Heintzmann, D.S. Lidke, C. Spagnuolo, O.E. Martinez, E.A. Jares-Erijman and T.M. Jovin. Ensemble and single particle photophysical properties (two-photon excitation, anisotropy, FRET, lifetime, spectral conversion) of commercial quantum dots in solution and in live cells. Micr. Res. Tech. 65, 169-179, 2004.
  • N. Schaffert, M. Hoßbach, R. Heintzmann, T. Achsel and R. Lührmann. RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodies. The EMBO J. 23, 3000-3009, 2004.
  • R. Heintzmann, K.A. Lidke, T.M. Jovin. Double-pass Fourier transform imaging spectroscopyOptics Express, 12, 753-763, 2004.
  • D.S. Lidke, P. Nagy, R. Heintzmann, D.J. Arndt-Jovin, J.N. Post, H. Grecco, E.A. Jares-Erijman and T.M. Jovin. Quantum dot ligands provide new insights in receptor-mediated signal transduction. Nature Biotechnology, 22, 198-203, 2004


  • R. Heintzmann.  Saturated patterned excitation microscopy with two-dimensional excitation patterns. Micron. 34, 283-291, 2003.
  • R. Heintzmann, V. Sarafis, P. Munroe, J. Nailon, Q.S. Hanley and T.M. Jovin.  Resolution enhancement by subtraction of confocal signals taken at different pinhole sizes.  Micron, 34, 293-300, 2003.


  • A. Cavallo, I. Solovei, L. Schermeleh, R. Heintzmann, T. Cremer, C. Cremer.  A Hybrid Approach to  the  3D  High  Precision  Position  Measurement  and  Particle  Tracking  in  Human  Cell Nuclei. Real-Time Imaging, 8, 467-473, 2002.
  • M. Heilemann, D.P. Herten, R. Heintzmann, C. Cremer, C. Müller, P. Tinnefeld, K.D. Weston, J. Wolfrum and M. Sauer. High-resolution colocalization of single dye molecules by fluorescence lifetime imaging microscopy.  Anal.  Chem., 74, 3511-3517, 2002.
  • R. Heintzmann, T.M. Jovin, and C. Cremer.  Saturated patterned excitation microscopy (SPEM) – a novel concept for optical resolution improvement.  J. Opt.  Soc.  Am.  A, 19, 1599-1609, 2002.
  • R. Heintzmann and C. Cremer. Axial tomographic confocal fluorescence microscopy, J. Microsc., 206, 7-23, 2002.


  • R. Heintzmann, Q.S Hanley, D. Arndt-Jovin, and T.M. Jovin. A dual path programmable array microscope – simultaneous acquisition of conjugate and non-conjugate images. J. Microsc., 204, 119-137, 2001.
  • R. Heintzmann and V. Sarafis. Two point resolution in incoherent imaging. Optik, 112, 114-118, 2001.
  • B. Albrecht, A.V. Failla, R. Heintzmann, and C. Cremer. Spatially modulated illumination mi­croscopy:  online visualization of intensity distribution and prediction of nanometer precision of axial distance measurements by computer simulations. J. Biomed.  Opt., 6, 292-299, 2001.


  • T. Cremer, G. Kreth, H. Koester, RHA. Fink, R. Heintzmann, M. Cremer, I. Solovei, D. Zink, and C. Cremer.  Chromosome territories,  interchromatin domain compartment, and nuclear matrix. An integrated view of the functional nuclear architecture. Critical Reviews in Eukaryotic Gene Expression, 10, 179-212, 2000.
  • R. Heintzmann, G. Kreth, and C. Cremer. Reconstruction of axial tomographic high resolution data from confocal fluorescence microscopy – a method for improving 3D FISH images.  Analytical Cellular Pathology , 20, 7-15, 2000.

Older Publications

  • O. Diat, P. Boesecke, C. Ferrero, A.K. Freund, J. Lambard, and R. Heintzmann. Ultra-small-angle x-ray scattering with a bonse-hart camera on the high brilliance beamline at the esrf.  Nuclear Instruments and Methods A, 356, 566-572, 1995.
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