• J. Nedbal, P.S. Hobson, D. J. Fear, R. Heintzmann, H. J. Gould, Comprehensive FISH Probe Design Tool Applied to Imaging Human Immunoglobulin Class Switch Recombination, PLOS ONE7, e51675, 2012
  • S. Cox, E. Rosten, J. Monypenny, T. Jovanovic-Talisman, D. T. Burnette, J. Lippincott-Schwartz, G. E. Jones und R.Heintzmann.Bayesian localization microscopy reveals nanoscale podosome dynamics.  Nature Methods 9, 195-200, 2012
  • S. Munck, K. Miskiewicz, R. Sannerud, S. A. Menchon, L Jose, R. Heintzmann, P. Verstreken und W. Annaert, Sub-diffraction imaging on standard microscopes through photobleaching microscopy with nonlinear processing, J. Cell Science 125,2257-2266, 2012
  • O. Mandula, M. Kielhorn, K. Wicker, G. Krampert, I. Kleppe, and R. Heintzmann, Line scan – structured illumination microscopy super-resolution imaging in thick fluorescent samples, Optics Express 20, 24167-24174, 2012
  • T. Ach, G. Best, S. Rossberger, R. Heintzmann, C. Cremer, S. Dithmar, Autofluorescence imaging of human RPE cell granules using structured illumination microscopy Br J Ophthalmol 96:1141-1144, 2012


  • G. Best, R. Amberger, D. Baddeley, T. Ach, S. Dithmar, R. Heintzmann, C. Cremer, Structured illumination microscopy of autofluorescent aggregations in human tissue, Micron 42, 330-335, 2011


  • K. Wicker, R. Heintzmann, Single-shot optical sectioning using polarization-coded structured illumination, J. Opt. 12, 084010, 2010
  • R. Heintzmann, Correcting distorted optics: back to the basics, Nature Methods 7, 108-110, 2010
  • L. Schermelleh, R. Heintzmann, H. Leonhardt, A guide to super-resolution fluorescence microscopy, J. Cell Biol 190, 165-175, 2010


  • R. Heintzmann, M.G.L. Gustafsson, The requirements for sub-diffraction resolution in continuous samples, Nature Photonics 3, 362-364, 2009
  • G. Liaugaudas, A. T. Collins, K. Suhling, G. Davies, R. Heintzmann, Luminescence-lifetime mapping in Diamond, J. Phys.: Condens. Matter 21, 364210. 2009
  • K. Wicker, S. Sindbert, R. Heintzmann, Characterisation of resolution enhancing image inversion interferometers, Optics Express 17, 15491-15501, 2009
  • L. Hirvonen, K. Wicker., O. Mandula and R. Heintzmann, Structured illumination microscopy of a living cell, Europ. Biophys. J. 38, 807-812, 2009
  • A. H. Reshak, V. Sarafis, R. Heintzmann, Second harmonic imaging of chloroplasts using the Two-Photon Laser Scanning Microscope, Micron 40, 378-385, 2009


  • M.Beutler, K. Makrogianneli, R.J. Vermeij, M. Keppler, T. Ng T.M. Jovin, R. Heintzmann, satFRET: estimation of Förster resonance energy transfer by acceptor saturation, Eur. Biophys. J. 38, 69-82, 2008
  • A. Hoppe, S. L. Shorte, J. A. Swanson, R. Heintzmann, D-FRET Reconstruction Microscopy for Analysis of Dynamic Molecular Interactions in Live Cells, Biophys. J. 95, 400-418, 2008
  • M. Barszczewski, J. J. Chua, A. Stein, U. Winter, R. Heintzmann, F. E. Zilly, D. Fasshauer, T. Lang, and R. Jahn, A Novel Site of Action for a-SNAP in the SNARE Conformational Cycle Controlling Membrane Fusion, Mol. Biol. Cell 19, 776-784, 2008


  • K. Wicker and R. Heintzmann, Interferometric resolution improvement for confocal microscopes, Optics Express 15, 12206- 12216, 2007.
  • C. Ventalon, R. Heintzmann, and J. Mertz, Dynamic speckle illumination microscopy with wavelet pre-filtering, Opt. Letters 32, 1417-1419, 2007.
  • T. J. Siddiqui, O. Vites, A. Stein, R. Heintzmann, R. Jahn, and D. Fasshauer, Determinants of Synaptobrevin regulation in membranes, Mol. Biol. Cell 18, 2037-2046, 2007
  • R. Heintzmann. Estimating Missing Information by Maximum Likelihood Deconvolution, Micron 38, 136-144, 2007
  • R. Heintzmann and C.J.R. Sheppard. The Sampling Limit in Fluorescence Microscopy, Micron 38, 145-149, 2007


  • V. Sarafis, R. Heintzmann, A. Karnieli, Visualizing Cyanobacteria in Soil Crusts from a Semi-Arid Environment using Confocal Fluorescence Imaging, Phytomorphology 56, 1-4, 2006
  • R. Heintzmann and G. Ficz. Breaking the resolution limit in light microscopy, Briefings in Functional Genomics and Proteomics 5, 289-301, 2006
  • R. Heintzmann and P.A. Benedetti, High-Resolution Image Reconstruction in Fluorescence Microscopy with Patterned Excitation, Applied Optics 45, 5037-5045, 2006.
  • J. J. Sieber, K. I. Willig, R. Heintzmann, S. W. Hell, T. Lang,  The SNARE-motif is essential for the formation of syntaxin clusters in the plasma membrane, Biophys. J. 90, 2843–2851, 2006.
  • R. F. Carvalho, M. Beutler, K. J.M. Marler, B. Knöll, E. Becker-Barroso, R. Heintzmann, T. Ng and U. Drescher, Silencing of EphA3 through a novel cis interaction with ephrinA5, NatureNeuroscience 9, 322-330, 2006


  • Q.S. Hanley, K.A. Lidke, R. Heintzmann, D.J. Arndt-Jovin, T.M. Jovin. Fluorescence lifetime imaging in an optically sectioning programmable array microscope (PAM), Cytometry Part A, 67A, 112-118, 2005.
  • G. Ficz, R. Heintzmann, D.J. Arndt-Jovin. Polycomb group protein complexes exchange rapidly in living Drosophila, Development 132, 3963-3976, 2005.
  • K.A. Lidke, B. Rieger, T.M. Jovin, R. Heintzmann. Superresolution by localization of quantum dots using blinking statistics. Opics Express 13, 7052-7062, 2005.
  • S.T. Berezhnaa, S. Schaefer, R. Heintzmann, M. Jahnz, G. Boese, A. Deniz, P. Schwille. New effects in polynucleotide release from cationic lipid carriers revealed by confocal imaging, fluorescence cross-correlation spectroscopy and single particle tracking. Biochimica et Biophysica Acta, 1669, 193-207, 2005.
  • M. A. Andrei, D. Ingelfinger, R. Heintzmann, T. Achsel, R. Rivera-Pomar, R. Lührmann, A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies, RNA 11, 717-727, 2005


  • E.A. Jares-Erijman, C. Spagnuolo, L. Giordano, M. Etchehon, J. Kawior, M.V. Mañalich-Arana, M. Bossi, D.S. Lidke, J.N. Post, R.J. Vermeij, R. Heintzmann, K.A. Lidke, D.J. Arndt-Jovin and T.M. Jovin: Novel (bio)chemical and (photo)physical probes for imaging live cells. In: Supramolecular Structure and Function, Vol. 8, G. Pifat-Mrzljak (ed.) Kluwer-Plenum Publishers, Amsterdam, pp. 99-118, 2004.
  • H.E. Grecco, K.A. Lidke, R. Heintzmann, D.S. Lidke, C. Spagnuolo, O.E. Martinez, E.A. Jares-Erijman and T.M. Jovin. Ensemble and single particle photophysical properties (two-photon excitation, anisotropy, FRET, lifetime, spectral conversion) of commercial quantum dots in solution and in live cells. Micr. Res. Tech. 65, 169-179, 2004.
  • N. Schaffert, M. Hoßbach, R. Heintzmann, T. Achsel and R. Lührmann. RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodies. The EMBO J. 23, 3000-3009, 2004.
  • R. Heintzmann, K.A. Lidke, T.M. Jovin. Double-pass Fourier transform imaging spectroscopyOptics Express, 12, 753-763, 2004.
  • D.S. Lidke, P. Nagy, R. Heintzmann, D.J. Arndt-Jovin, J.N. Post, H. Grecco, E.A. Jares-Erijman and T.M. Jovin. Quantum dot ligands provide new insights in receptor-mediated signal transduction. Nature Biotechnology, 22, 198-203, 2004


  • R. Heintzmann.  Saturated patterned excitation microscopy with two-dimensional excitation patterns. Micron. 34, 283-291, 2003.
  • R. Heintzmann, V. Sarafis, P. Munroe, J. Nailon, Q.S. Hanley and T.M. Jovin.  Resolution enhancement by subtraction of confocal signals taken at different pinhole sizes.  Micron, 34, 293-300, 2003.


  • A. Cavallo, I. Solovei, L. Schermeleh, R. Heintzmann, T. Cremer, C. Cremer.  A Hybrid Approach to  the  3D  High  Precision  Position  Measurement  and  Particle  Tracking  in  Human  Cell Nuclei. Real-Time Imaging, 8, 467-473, 2002.
  • M. Heilemann, D.P. Herten, R. Heintzmann, C. Cremer, C. Müller, P. Tinnefeld, K.D. Weston, J. Wolfrum and M. Sauer. High-resolution colocalization of single dye molecules by fluorescence lifetime imaging microscopy.  Anal.  Chem., 74, 3511-3517, 2002.
  • R. Heintzmann, T.M. Jovin, and C. Cremer.  Saturated patterned excitation microscopy (SPEM) – a novel concept for optical resolution improvement.  J. Opt.  Soc.  Am.  A, 19, 1599-1609, 2002.
  • R. Heintzmann and C. Cremer. Axial tomographic confocal fluorescence microscopy, J. Microsc., 206, 7-23, 2002.


  • R. Heintzmann, Q.S Hanley, D. Arndt-Jovin, and T.M. Jovin. A dual path programmable array microscope – simultaneous acquisition of conjugate and non-conjugate images. J. Microsc., 204, 119-137, 2001.
  • R. Heintzmann and V. Sarafis. Two point resolution in incoherent imaging. Optik, 112, 114-118, 2001.
  • B. Albrecht, A.V. Failla, R. Heintzmann, and C. Cremer. Spatially modulated illumination mi­croscopy:  online visualization of intensity distribution and prediction of nanometer precision of axial distance measurements by computer simulations. J. Biomed.  Opt., 6, 292-299, 2001.


  • T. Cremer, G. Kreth, H. Koester, RHA. Fink, R. Heintzmann, M. Cremer, I. Solovei, D. Zink, and C. Cremer.  Chromosome territories,  interchromatin domain compartment, and nuclear matrix. An integrated view of the functional nuclear architecture. Critical Reviews in Eukaryotic Gene Expression, 10, 179-212, 2000.
  • R. Heintzmann, G. Kreth, and C. Cremer. Reconstruction of axial tomographic high resolution data from confocal fluorescence microscopy – a method for improving 3D FISH images.  Analytical Cellular Pathology , 20, 7-15, 2000.

Older Publications

  • O. Diat, P. Boesecke, C. Ferrero, A.K. Freund, J. Lambard, and R. Heintzmann. Ultra-small-angle x-ray scattering with a bonse-hart camera on the high brilliance beamline at the esrf.  Nuclear Instruments and Methods A, 356, 566-572, 1995.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.